Vascular dysfunction and pathology: focus on mechanical forces

in Vascular Biology
View More View Less
  • 1 G Garoffolo, Centro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milano, Italy
  • 2 M Pesce, Unità di Ingegneria Tissutale Cardiovascolare, Centro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico, Milano, 20138, Italy

Correspondence: Gloria Garoffolo, Email: gloria.garoffolo@ccfm.it

The role of mechanical forces is emerging as a new player in pathophysiologic programming of the cardiovascular system. The ability of the cells to ‘sense’ mechanical forces does not relate only to perception of movement or flow, as intended traditionally, but also to the biophysical properties of the extracellular matrix, the geometry of the tissues and the force distribution inside them. This is also supported by the finding that cells can actively translate mechanical cues into discrete gene expression and epigenetic programming. In the present review we will contextualize these new concepts in the vascular pathologic programming.

 

Sept 2018 onwards Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 37 37 37
PDF Downloads 51 51 51