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Piotr Kobialka and Mariona Graupera

pathological vessel growth Perturbations in class I PI3K signalling have been linked to aberrant vascular growth including tumour angiogenesis and vascular malformations. The impact of PI3K inhibitors on tumour vessels Angiogenesis is a rate

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Timothy D Le Cras and Elisa Boscolo

). PIK3CA mutations in vascular anomalies While vascular malformations are primarily present at birth, they can also become apparent during childhood, and they persist throughout adulthood. The International Society for the Study of Vascular Anomalies

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Aurélie Hautefort, Anna Pfenniger and Brenda R Kwak

Introduction Intercellular communication is important for vascular function and homeostasis. Connexins (Cxs) play an essential role in this crosstalk. Cxs are ubiquitous transmembrane proteins, which have the ability to form hemichannels at

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David Mellis and Andrea Caporali

Introduction to miRNAs in vascular biology MicroRNAs (miRNAs) are a member of the small non-coding RNA family; they are ~22 nucleotides and are strong post-transcriptional regulator of gene expression. The specificity of miRNA targeting is

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Amer Harky, Ka Siu Fan and Ka Hay Fan

rupture of arteries, intestines and uterus ( 20 ). Vascular EDS (type IV, OMIM# 130050) has the worst prognosis of all EDS types due to vascular complications with type III collagen dysfunction. This is an autosomal dominant pathology that primarily

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Makeda Stephenson, Daniel H Reich and Kenneth R Boheler

Introduction Vascular smooth muscle cells (vSMCs) develop from cell lineage precursors and progenitors to form a layer of non-striated contractile mural cells located between the tunica media and tunica adventitia of blood vessels which