Department of Cardiology, Tianjin First Central Hospital, Tianjin, China
Department of Cardiology, Longgang People’s Hospital of Shenzhen, Shenzhen, Guangdong, China
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Department of Cardiology, Tianjin First Central Hospital, Tianjin, China
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Introduction Vascular calcification is a common condition noted in aging, atherosclerosis, hypertension, diabetes, dyslipidemia, valvular heart disease, and chronic kidney disease ( 1 , 2 ). It is caused by heterotopic deposition of
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similarities and differences in calcific pathological development between heart valves and blood vessels. Of particular focus is the role that oscillatory blood flow patterns play in biomechanical-induced activation of diseased pathways in valvular vs vascular
Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
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and contributed to neointima formation in response to acute vascular injury. During chronic vascular injury, Gli1+ MSCs differentiated into osteoblast-like cells and accelerated vascular calcification. Inducible lineage tracing of c-Kit lineage cells
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cell types present within the (cardio)vascular system, which all are crucial players in the field, and also vascular (re)modelling, regeneration, calcification, animal models and alternative models, imaging technologies, biochemical and biomechanics
Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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salts or hydroxyapatite in the vascular wall (vascular calcification) not only contributes to vascular stiffness but is a major risk factor for the morbidity and mortality associated with CVDs including atherosclerosis ( 85 ). As mentioned earlier, VSMCs
Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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on vascular calcification by inhibiting endothelial BMP/SMAD1/5 signaling . Circulation Research 2021 129 e87 – e100 . ( https://doi.org/10.1161/CIRCRESAHA.120.318690 ) 17 Hergenreider E Heydt S Tréguer K Boettger T Horrevoets AJG Zeiher
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example, cyclic strain induces arterial stiffening of large arteries, contributing to vascular calcification. Indeed, due to calcific plaque that affects vessel patency, the velocity of the blood flow increases with consequent effects on blood pressure
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Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy
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University Hospitals Bristol, NHS Foundation Trust, Bristol, UK
Bristol Medical School, University of Bristol, Bristol, UK
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Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy
University Hospitals Bristol, NHS Foundation Trust, Bristol, UK
Bristol Medical School, University of Bristol, Bristol, UK
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near equivalent to that of magnetic resonance scans ( 17 ). Furthermore, DSCT allows for more accurate assessment of calcified plaque volume, as it uses two x-ray sources with different energies to achieve more detailed Hounsfield unit measurements ( 18
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). On the other hand, Badi et al . showed that miR-34a is upregulated in aged murine aortas, where it promoted the senescent process and vascular calcification of VSMCs ( 24 ), a well-known complication of atherosclerosis. A recent study pointed out
Interventional Cardiac Electrophysiology Group, International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic
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Nanobiotechnology, CEITEC-MU, Brno, Czech Republic
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First Department of Internal Medicine, Cardioangiology, St. Anne’s University Hospital Brno, Masaryk University, Brno, Czech Republic
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Nanotechnology and stem cells hold a great clinical promise in the field of vascular therapies. Presented review provides an up-to-date summary about advances and challenges associated with these novel treatment strategies. Nanotechnology
