Department of Cardiology, Tianjin First Central Hospital, Tianjin, China
Department of Cardiology, Longgang People’s Hospital of Shenzhen, Shenzhen, Guangdong, China
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Department of Cardiology, Tianjin First Central Hospital, Tianjin, China
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angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts . Cardiovascular Research 2007 75 702 – 709 . ( https://doi.org/10.1016/j.cardiores.2007.02.015 ) 10.1016/j.cardiores.2007.02.015 16 Zeadin M Butcher M Werstuck G Khan
Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
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. The medial layer consists mostly of smooth muscle cells (SMCs) and a small number of MSCs. The adventitial layer hosts a heterogenous population of cells including fibroblasts, inflammatory cells, microvascular cells and a variety of MSCs ( 8
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SMCs (and adventitial fibroblasts) synthesize the ECM components and ECM-modifying enzymes that play an important role in arterial stiffness. However, the degree to which SMCs make and secrete ECM components is thought to depend on their differentiation
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heart. Pericytes in the normal myocardium The adult mammalian heart contains abundant interstitial cells, including fibroblasts, pericytes and macrophages ( 13 , 14 ). Early ultrastructural studies have identified a large population of pericytes
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Heart and Vascular Center, Semmelweis University, Budapest, Hungary
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characterised angiogenic components used include VEGF, FGF2 (fibroblast growth factor 2), EGF and IGF1 (insulin-like growth factor 1). Alternatively, some media are supplemented with defined concentrations of recombinant growth factors, whereas other media
Interventional Cardiac Electrophysiology Group, International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic
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Nanobiotechnology, CEITEC-MU, Brno, Czech Republic
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First Department of Internal Medicine, Cardioangiology, St. Anne’s University Hospital Brno, Masaryk University, Brno, Czech Republic
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prior to clinical step. hiPSCs can be derived from patient-specific somatic cells (i.e. fibroblast), and they can be differentiated into ECs ( 46 ), which express angiogenic and reendothelialization potential upon exposure to shear stress ( 46 , 47
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pulmonary adventitial fibroblasts, miR-124 normalizes the ratio of PKM2/PKM1 via PTBP1, consequently inhibiting the proliferation and the migration of the fibroblast ( 156 ). miR-204 is also downregulated in hypoxia and targets SHP2 phosphatase, thus
