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Dwitiya Sawant and Brenda Lilly

estimated 2000 mature miRNAs are encoded by the human genome ( 4 ). miR-145 was first identified as a novel tissue-specific miRNA expressed in murine hearts ( 5 ). Since this initial report in 2002, miR-145 has garnered much attention, with 1708 PubMed

Open access

David Mellis and Andrea Caporali

-503 Downregulation Extracellular from ECs to pericytes Increase vessels permeability (5) miR-126 Upregulation Extracellular from ECs to Ecs Re-endothelisation (21) miR-143-145 Upregulation Extracellular from ECs to

Open access

Ornella Colpani and Gaia Spinetti

of miR-126 were found in the athero-susceptible areas characterized by disturbed flow ( 29 ). Other atheroprotective miRNAs are miR-143/145, which are upregulated in EC under laminar shear stress and which target gene expression in VSMCs ( 30

Open access

Alessandra Magenta, Reggio Lorde, Sunayana Begum Syed, Maurizio C Capogrossi, Annibale Puca, and Paolo Madeddu

upregulation has been linked to aging. In particular, miRNA-200c and miR-141 expressions are increased in skeletal muscles and arteries of aging rhesus monkeys and mice ( 15 , 16 ). miRNA-141 and miRNA-200c increase with aging in human liver ( 17 ). In

Open access

Malik Bisserier, Radoslav Janostiak, Frank Lezoualc’h, and Lahouaria Hadri

. Indeed, miR-17/29 ; -21 ; -20a ; -135a ; -23a targets BMPR2 and regulates proliferation and differentiation of PASMC and PAECs ( 122 , 123 , 132 , 145 , 146 ). Additionally, miR-322 targets other members of the cascade, namely BMPR1 and Smad5

Open access

Sarah Costantino, Shafeeq A Mohammed, Samuele Ambrosini, and Francesco Paneni

-related cardiovascular damage. Several miRNAs, including miR-320b, miR-29b, miR-1, miR-133a and miR-499 were found to be involved in the persistence of myocardial damage despite intensive glycemic control ( 53 ). Targeting these miRNAs, which are actively involved in

Open access

Linda Alex and Nikolaos G Frangogiannis

attenuated adverse remodeling and improved systolic dysfunction, by secreting angiogenic mediators (such as VEGF and angiopoietin-1) and by releasing protective microRNAs ( 75 ). Pericyte-derived miR-132 was identified a key cardioprotective factor that

Open access

Luca Marchetti and Britta Engelhardt

-integrin function blocking antibodies (27, 145)  ICAM-1 Activated rodent CD4 and CD8 T cells In vitro imaging of T cell and neutrophil interaction with mouse models of the BBB under physiological flow (94, 106)  ICAM-2 Activated