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Jaana Schneider, Marianne Pultar and Wolfgang Holnthoner

tissue-engineered constructs. Moreover, a number of studies investigated the complex interplay with the ECM. Different proteases like plasmin or matrix metalloproteinases ( 16 ) have been shown to be key players in the morphogenesis and the remodeling of

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Makeda Stephenson, Daniel H Reich and Kenneth R Boheler

. were able to use these defined cells to engineer more elastic and functional vascular smooth muscle tissue constructs ( 38 ). Kumar et al . demonstrated that inhibition of MEK signaling, which is required for the support of protein synthesis in SMCs

Open access

Jarkko P Hytönen, Olli Leppänen, Jouni Taavitsainen, Petra Korpisalo, Svetlana Laidinen, Kari Alitalo, Jonas Wadström, Tuomas T Rissanen and Seppo Ylä-Herttuala

Evans ND Stevens MM. Complexity in biomaterials for tissue engineering . Nature Materials 2009 8 457 – 470 . ( https://doi.org/10.1038/nmat2441 ) 3 Atala A Bauer SB Soker S Yoo JJ Retik AB. Tissue-engineered autologous bladders for patients

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Eleonora Zucchelli, Qasim A Majid and Gabor Foldes

same cell type is cultured in 3D instead of 2D. 3D cell cultures can be therefore well used in the optimisation of tissue-engineered cell therapy manufacturing, including adequate vascularisation. To study the effect of biomaterials and growth factors

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Xuechong Hong and Wenduo Gu

muscle, bone, adipose and cartilage cells ( 1 ). MSCs isolated from multiple different organs and tissues commonly share similar features in in vitro settings. However, the characteristics and function of MSCs in their endogenous in vivo environment

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Ebba Brakenhielm and Vincent Richard

engineered tissues . Acta Biomaterialia 2018 69 42 – 62 . ( https://doi.org/10.1016/j.actbio.2018.01.017 ) 3 Carrabba M Madeddu P . Current strategies for the manufacture of small size tissue engineering vascular grafts . Frontiers in

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Ambra Cappelletto and Serena Zacchigna

, cell therapy has been considered to promote neovascularization and tissue repair after cardiac ischemia. Cells can be either engineered and used as vehicles to deliver growth factors or directly exploited for their pro-angiogenic properties ( 9 , 10

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Tomasz Jadczyk, Guido Caluori, Wojciech Wojakowski and Zdenek Starek

therapeutic applications. MCSs are present in multiple organs ( 29 ) throughout human body including adipose tissue (adipose-derived stromal/stem cells, ASCs) and umbilical cord, which provides an easily accessible and expandable source of cells for clinical

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Ornella Colpani and Gaia Spinetti

induce a DNA damage response in neighboring cells via gap junction and processes involving reactive oxygen species generation ( 6 ). Therefore, senescence-associated changes in tissues may predispose to the development of diseases including those of the

Open access

Malik Bisserier, Radoslav Janostiak, Frank Lezoualc’h and Lahouaria Hadri

cell. The World Health Organization classifies PH into five groups based on the underlying etiology ( 8 ) ( Fig. 2 ). Group 1 (PAH) refers to idiopathic or inherited PAH, drug or toxins induced, connective tissue and heart diseases, human