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Healthy Lifespan Institute HELSI, University of Sheffield, Medical School, Sheffield, UK
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-1β by caspase-1 ( 9 ). Active IL-1β can then be associated with the NLRP3 inflammasome ( 10 ). Only active IL-1β is released from cells and there is a myriad of mechanisms proposed, mainly in monocytic cells, including through microvesicles
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Universita’ della Svizzera Italiana, Lugano, Switzerland
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MEBIC Consortium, San Raffaele Open University, Rome, Italy
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San Raffaele Open University, Rome, Italy
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trafficking during autophagy and the attenuation of the apoptotic response through prevention of caspases activation. Finally, extracellular HMGB1 regulates the crosstalk autophagy/apoptosis by binding to the Receptor for Advanced Glycation End products (RAGE
Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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± 2 10 ± 4 VSMCs (%) 6 ± 2 7 ± 2 0.6 ± 0.2 0.5 ± 0.2 Fibrous cap (µm) 4.4 ± 1.0 3.1 ± 0.5 2.1 ± 0.6 2.5 ± 0.6 Cleaved caspase-3 (%) 0.6 ± 0.3 1.0 ± 0.3 4 ± 3 2 ± 1 Independent samples t -test
Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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endothelial cell line, hCMEC/D3 ( 63 ). Instead, in these cells, TRAIL stimulated caspase-1 activity and cell death ( 60 , 63 ). These discrepancies may reflect receptor expression, cell type, origin, or differences in the in vitro angiogenic assay methods
Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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collagen (%) 23 ± 3 25 ± 3 ICAM-1-positive ECs (%) 81 ± 4 94 ± 4 b VCAM-1-positive ECs (%) 44 ± 7 58 ± 10 Cleaved caspase 3 (%) 0.10 ± 0.03 0.03 ± 0.01 a Independent samples t -test. a P < 0.05, b P
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associated with both PASI improvement and local inflammatory response decrease ( 36 ). Interestingly, in MI, miR-135b is downregulated, and its overexpression attenuates pyroptosis, a caspase-1-dependent proinflammatory programmed cell death. Thus, miR-135b
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Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA
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Introduction miRNAs are a group of small (~22 nucleotides in length) ncRNA molecules that functionally fine tune gene expression through post-transcriptional regulation ( 1 ). Since their discovery in the nematode Caenorhabditiselegans in
Department of Cardiology, Tianjin First Central Hospital, Tianjin, China
Department of Cardiology, Longgang People’s Hospital of Shenzhen, Shenzhen, Guangdong, China
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Department of Cardiology, Tianjin First Central Hospital, Tianjin, China
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Introduction Vascular calcification is a common condition noted in aging, atherosclerosis, hypertension, diabetes, dyslipidemia, valvular heart disease, and chronic kidney disease ( 1 , 2 ). It is caused by heterotopic deposition of
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University Heart Center, Cardiology, University Hospital Zurich, Zürich, Switzerland
Department of Research and Education, University Hospital Zurich, Zürich, Switzerland
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impaired glucose tolerance and 592 million people will have diabetes worldwide ( 1 ). A recent study analysing data from 6,264,226 adults (18 years of age or older) who participated in the Behavioral Risk Factor Surveillance System Survey (1993–1994 and
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will be outlined with respect to attenuating chemotherapy-induced cardiovascular toxicity. Figure 1 Mechanisms of chemotherapy-induced apoptosis via activation of caspase cascade. ROS, reactive oxygen species. The detrimental effects of
