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Dwitiya Sawant and Brenda Lilly

articles with miR-145 in the title or abstract as of October 2020. Nearly 60%, or 1017 of these publications are cancer-related studies, while 210 or only 12% are cardiovascular-associated. The importance of miR-145 in the cardiovascular system became

Open access

Alessandra Magenta, Reggio Lorde, Sunayana Begum Syed, Maurizio C Capogrossi, Annibale Puca, and Paolo Madeddu

miRNAs are either epigenetically regulated or represent epi-miRNAs involved in aging and in cardiovascular regeneration and are summarized in Fig. 1 . Figure 1 Biological effects of Epi-miRNAs. The miRNA-200 family The miRNA-200

Open access

Carlo Dal Lin, Francesco Tona, and Elena Osto

‘barometer’ of cardiovascular health and is useful in prognosis evaluation and in therapeutic patient management ( 2 , 3 , 4 ). In fact, not only cardiovascular risk factors ( 2 , 3 , 4 ), but also several neuroendocrine and immunometabolic diseases

Open access

Stephen P Gray, Ajay M Shah, and Ioannis Smyrnias

, regulation and expression of the main NOXs in the cardiovascular system). Under physiological conditions, NOX4 was first identified and has its highest levels of expression in kidney proximal tubular cells ( 2 ), but is also expressed in many other cell types

Open access

Cristina Caffarra Malvezzi, Aderville Cabassi, and Michele Miragoli

Introduction Cardiovascular diseases (CVDs), with almost 18 million deaths per year, are the first cause of death globally (World Health Organization). The heart is one of the most energy-demanding organs in the body, due to its intrinsic

Open access

Paolo Madeddu

. Additionally, myocardial injury is present in more than a quarter of critical cases, manifesting either acutely on presentation or more insidiously as illness severity intensifies ( 1 , 2 , 3 , 4 ). Clinical signs of cardiovascular disease include chest

Open access

James T Pearson, Mikiyasu Shirai, Vijayakumar Sukumaran, Cheng-Kun Du, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T Waddingham, Rajesh Katare, and Daryl O Schwenke

both the central nervous system and the cardiovascular system and is particularly important for the protection of endothelial cell function ( 3 ). The gut is the largest producer of this peptide, but the heart and vasculature also express ghrelin at

Open access

Manisha S Patil, Siân P Cartland, and Mary M Kavurma

, TRAIL can contribute to cell survival, proliferation, migration and differentiation ( 7 , 8 , 9 ) and in doing so modulate vascular remodelling in cardiovascular diseases (CVDs). Furthermore, in many vascular cells, TRAIL has been linked to regulating

Open access

Chia-Pei Denise Hsu, Joshua D Hutcheson, and Sharan Ramaswamy

Introduction The cardiovascular system consists of a complex network of blood vessels that facilitates the flow of blood from the heart to the rest of the body. As the first fully functional organ system to form during embryonic development

Open access

Abdallah Al-Mohammad, David G Partridge, Graham Fent, Oliver Watson, Nigel T Lewis, Robert F Storey, Michael Makris, and Timothy J Chico

associated with a range of cardiac complications. At the time of first submission of this review, a PubMed search of ‘COVID’ and ‘Cardiovascular’ yielded 653 studies; this had increased to 3055 by the time of final submission. A number of excellent reviews