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Dwitiya Sawant and Brenda Lilly

articles with miR-145 in the title or abstract as of October 2020. Nearly 60%, or 1017 of these publications are cancer-related studies, while 210 or only 12% are cardiovascular-associated. The importance of miR-145 in the cardiovascular system became

Open access

Ruth Ganss

Introduction Cancer and stromal accessory cells co-evolve to foster malignant growth and tumour progression. Among stromal cells, tumour blood vessels have been a major focus in oncology. It has been shown in the early 1970s that the rate of

Open access

Timothy D Le Cras and Elisa Boscolo

by R, arginine or L, leucine at amino acid position 1047) in exon 20 (kinase domain) are common in cancer ( 6 ), and more recently, have also been identified in pediatric vascular anomalies and overgrowth syndromes. All of the PIK3CA mutations

Open access

Paolo Madeddu

soluble morphogenic factors are required for cancer angiogenesis. Many other radically transformative paradigms have been introduced in the last decades. To name a few, the molecular search for the identity of master regulators of vascular tone led to the

Open access

Malik Bisserier, Radoslav Janostiak, Frank Lezoualc’h, and Lahouaria Hadri

role in cancer and cardiovascular diseases ( 23 , 24 , 25 , 26 ). For instance, abnormal hyper-methylation in the promoter region of the tumor suppressor genes has been described as one of the key mediators in tumorigenesis, while hypo-methylation is

Open access

Piotr Kobialka and Mariona Graupera

-limiting step in tumour growth; therefore, the concept of eradicating cancer by inhibiting neoangiogenesis was conceived as a unique opportunity. Nevertheless, blocking VEGF failed to improve survival as a monotherapy. Instead, a combination of anti

Open access

Alessandra Magenta, Reggio Lorde, Sunayana Begum Syed, Maurizio C Capogrossi, Annibale Puca, and Paolo Madeddu

/medical welfare are in the agenda of policy makers and governmental agencies. All around the world, scientists are trying to beat age-related diseases, such as heart attacks, cancer, and dementia; stop people getting ill is an obvious goal to aid the individual

Open access

Nektarios Barabutis

/2 kinases, JAK2/STAT3). They exert their protective activities in the vasculature via P53 induction and by suppressing the LPS-induced P53 phosphorylation (degradation) ( 8 ). Another class of advanced anti-cancer agents, namely the growth hormone releasing

Open access

T Scott Bowen and Stuart Egginton

a major contribution to the aetiology and maintenance of multiple disorders, including those associated with serious risk of mortality and/or level of morbidity, such as cancer, cardiovascular disease, diabetes, stroke, age-related blindness

Open access

Tomasz Jadczyk, Guido Caluori, Wojciech Wojakowski, and Zdenek Starek

panorama of fields like cardiovascular intervention, neurological and cancer treatment ( 2 ). The devised technologies, relatively to their aim and complexity, face several translational challenges and attrition ( 3 ). Nanoparticles, such as liposomal