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Xiaojing Ma Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Hongfei Li Department of Biological Sciences, Mount Holyoke College, South Hadley, Massachusetts, USA

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Shuntian Zhu Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Zixuan Hong Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Weijing Kong Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Qihang Yuan Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Runlong Wu Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Zihang Pan Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Jing Zhang Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, China

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Yahong Chen Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, China

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Xi Wang Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York, USA

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Kai Wang Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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vascularization is achieved. During organ development, blood vessels usually grow simultaneously to not only nourish but also remodel and reshape the organs. Lack of vascularization limits the size, complexity, maturation and function of organoids. Emerging

Article Type:
Review Article
DOI:
https://doi.org/10.1530/VB-22-0001
Volume/Issue:
Volume 4: Issue 1
Open access
Catarina G Fonseca Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal

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Pedro Barbacena Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal

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Claudio A Franco Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal

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physically connected via the lymphatic thoracic duct, where lymph returns macromolecules and extravasated fluid to the blood circulation. Blood vessels arise during early embryonic development. De novo formation of blood vessels – vasculogenesis – is

Article Type:
Mini Review
DOI:
https://doi.org/10.1530/VB-20-0007
Volume/Issue:
Volume 2: Issue 1
Open access
Manisha S Patil Heart Research Institute, Sydney, Australia
Faculty of Medicine and Health, University of Sydney, Sydney, Australia

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Siân P Cartland Heart Research Institute, Sydney, Australia
Faculty of Medicine and Health, University of Sydney, Sydney, Australia

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Mary M Kavurma Heart Research Institute, Sydney, Australia
Faculty of Medicine and Health, University of Sydney, Sydney, Australia

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Introduction Blood vessels, consisting of arteries, arterioles, capillaries, venules and veins, are channels with intricate networks that supply blood around the body and remove waste. Most blood vessels are composed of three layers ( Fig. 1

Article Type:
Review Article
DOI:
https://doi.org/10.1530/VB-20-0005
Volume/Issue:
Volume 2: Issue 1
Open access
Elisabeth Kugler Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
The Bateson Centre, Firth Court, University of Sheffield, Western Bank, Sheffield, UK
Insigneo Institute for in silico Medicine, Sheffield, UK
Institute of Ophthalmology, Faculty of Brain Sciences, University College London, London, UK

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Ryan Snodgrass Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
The Bateson Centre, Firth Court, University of Sheffield, Western Bank, Sheffield, UK

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George Bowley Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
The Bateson Centre, Firth Court, University of Sheffield, Western Bank, Sheffield, UK

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Karen Plant Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
The Bateson Centre, Firth Court, University of Sheffield, Western Bank, Sheffield, UK

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Jovana Serbanovic-Canic Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
The Bateson Centre, Firth Court, University of Sheffield, Western Bank, Sheffield, UK

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Noémie Hamilton Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
The Bateson Centre, Firth Court, University of Sheffield, Western Bank, Sheffield, UK

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Paul C Evans Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
The Bateson Centre, Firth Court, University of Sheffield, Western Bank, Sheffield, UK
Insigneo Institute for in silico Medicine, Sheffield, UK

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Timothy Chico Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
The Bateson Centre, Firth Court, University of Sheffield, Western Bank, Sheffield, UK

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Paul Armitage Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
Insigneo Institute for in silico Medicine, Sheffield, UK

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), the zebrafish basic body plan is established and cardiac contraction starts. Within this timeframe, vasculogenesis forms the primary vessels ( 16 , 17 ). Blood flow plays an important role in processes, such as EC polarization, vascular lumenization

Article Type:
Research Article
DOI:
https://doi.org/10.1530/VB-21-0009
Volume/Issue:
Volume 3: Issue 1
Open access
Sarah Schnabellehner Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

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Marle Kraft Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

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Hans Schoofs Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

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Henrik Ortsäter Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

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Taija Mäkinen Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

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Introduction Blood and lymphatic vessels fulfill important homeostatic functions and play a role in numerous diseases. The endothelial cells (ECs) of blood and lymphatic vessels develop during early embryogenesis and differentiate into

Article Type:
Research Article
DOI:
https://doi.org/10.1530/VB-23-0014
Volume/Issue:
Volume 6: Issue 1
Open access
Ruth Ganss Vascular Biology and Stromal Targeting, Harry Perkins Institute of Medical Research, The University of Western Australia, Centre for Medical Research, Nedlands, Western Australia, Australia

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Introduction Cancer and stromal accessory cells co-evolve to foster malignant growth and tumour progression. Among stromal cells, tumour blood vessels have been a major focus in oncology. It has been shown in the early 1970s that the rate of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/VB-19-0032
Volume/Issue:
Volume 2: Issue 1
Open access
Emily Warren Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA

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Sharon Gerecht Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA

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microvascular systems is incorporating multiple cell types in a physiologically relevant environment and spatial arrangement. Interactions between endothelial and mural cells are critical for forming and stabilizing the vasculature. Blood vessels are lined with

Article Type:
Review Article
Collections:
Beyond the endothelium: the role of mural cells
DOI:
https://doi.org/10.1530/VB-22-0021
Volume/Issue:
Volume 5: Issue 1
Open access
Ambra Cappelletto Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy

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Serena Zacchigna Cardiovascular Biology Laboratory, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy

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Mechanisms of vessel formation Over recent decades, the epidemic of cardiovascular disorders, and in particular cardiac ischemia, has raised an enormous interest on the mechanisms sustaining blood vessel formation, with the final goal of

Article Type:
Mini Review
DOI:
https://doi.org/10.1530/VB-19-0011
Volume/Issue:
Volume 1: Issue 1
Open access
Miesje M van der Stoel Amsterdam UMC, University of Amsterdam, location AMC, Amsterdam Cardiovascular Sciences, Department of Medical Biochemistry, Meibergdreef, Amsterdam, The Netherlands

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Maria P Kotini Biozentrum der Universität Basel, Spitalstrasse, Basel, Switzerland

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Rianne M Schoon Amsterdam UMC, University of Amsterdam, location AMC, Amsterdam Cardiovascular Sciences, Department of Medical Biochemistry, Meibergdreef, Amsterdam, The Netherlands

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Markus Affolter Biozentrum der Universität Basel, Spitalstrasse, Basel, Switzerland

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Heinz-Georg Belting Biozentrum der Universität Basel, Spitalstrasse, Basel, Switzerland

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Stephan Huveneers Amsterdam UMC, University of Amsterdam, location AMC, Amsterdam Cardiovascular Sciences, Department of Medical Biochemistry, Meibergdreef, Amsterdam, The Netherlands

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vascular development ( 34 ). Nevertheless, the vcl- KO embryos develop functional blood vessels and no evident haemorrhages were observed ( 34 ). To assess the permeability of the endothelial barrier, the 10 kDa rhodamine-dextran tracer was injected into

Article Type:
Research Article
DOI:
https://doi.org/10.1530/VB-22-0012
Volume/Issue:
Volume 5: Issue 1
Open access
Ebba Brakenhielm Normandy University, UniRouen, Inserm (Institut National de la Santé et de la Recherche Médicale) UMR1096 (EnVI Laboratory), FHU REMOD-VHF, Rouen, France

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Vincent Richard Normandy University, UniRouen, Inserm (Institut National de la Santé et de la Recherche Médicale) UMR1096 (EnVI Laboratory), FHU REMOD-VHF, Rouen, France

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Introduction Over the last 15 years, the use of anti-angiogenic agents to inhibit blood vessel growth has clearly established its ‘raison d’être’ in the treatment of human diseases, including multiple types of cancer, but also vascular

Article Type:
Mini Review
DOI:
https://doi.org/10.1530/VB-19-0006
Volume/Issue:
Volume 1: Issue 1
Open access