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extracellular matrix and biomechanical difference of the thoracic aorta in hypertensive mice models to understand the varying susceptibility to disease in different sections of the aorta ( 49 ). The hypertensive models demonstrated disrupted intrinsic material

connective tissue degeneration and biomechanical changes, TAA distinguishes itself from the signature inflammatory changes in abdominal aortic aneurysms (AAAs) with its heavier genetic involvements ( 5 , 7 ). Alongside well-known genetic syndromes, there are

during zebrafish vascular development . Cell Reports 2014 6 799 – 808 . ( https://doi.org/10.1016/j.celrep.2014.01.032 ) 130 Baeyens N Schwartz MA . Biomechanics of vascular mechanosensation and remodeling . Molecular Biology of the Cell

similarities and differences in calcific pathological development between heart valves and blood vessels. Of particular focus is the role that oscillatory blood flow patterns play in biomechanical-induced activation of diseased pathways in valvular vs vascular

their 3D environment. In addition, these microcapillary structures can produce their own ECM consisting of perlecan, collagen IV and laminin ( 14 ). Interestingly, the analysis of biomechanical properties of the ECM revealed local stiffness to be quite

of biomechanical genes establishes tissue stiffness homeostasis . Nature Cell Biology 2019 21 . ( https://doi.org/10.1038/s41556-019-0272-y ) 13 Treiber T Treiber N Plessmann U Harlander S Daiss JL Eichner N Lehmann G Schall K

culture systems . Biomechanics and Modeling in Mechanobiology 2019 717 – 731 . ( https://doi.org/10.1007/s10237-018-01111-3 ) 50 Vernon RB Sage EH . A novel, quantitative model for study of endothelial cell migration and sprout formation

profile of cells cultured in monolayers also was shown to be significantly different than that of cells cultured in 3D environments. These findings, along with an understanding of differences in biomechanical force and transduction acting on cells in 2D