Jamie I van der Vaart
Jamie I van der Vaart
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Robin van Eenige
Robin van Eenige
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Patrick C N Rensen
Patrick C N Rensen
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Sander Kooijman
Sander Kooijman
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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is atherosclerosis, a progressive disorder characterized by a thickening of arterial walls and narrowing of the arteries due to the formation of atherosclerotic plaques, that is, accumulation of cholesterol, macrophages, and cell debris in the intima
Isabelle Coornaert
Isabelle Coornaert
Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium
Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Annelies Breynaert
Annelies Breynaert
NatuRAPT Research Group, University of Antwerp, Antwerp, Belgium
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Nina Hermans
Nina Hermans
NatuRAPT Research Group, University of Antwerp, Antwerp, Belgium
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Guido R Y De Meyer
Guido R Y De Meyer
Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium
Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Wim Martinet
Wim Martinet
Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium
Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Introduction Atherosclerosis is a progressive inflammatory disease of large- and medium-sized arteries characterized by the formation of plaques in the arterial wall ( 1 ). Lipid oxidation plays a critical role in atherogenesis ( 2 ). When
Isabelle Coornaert
Isabelle Coornaert
Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium
Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Annelies Breynaert
Annelies Breynaert
NatuRAPT Research Group, University of Antwerp, Antwerp, Belgium
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Nina Hermans
Nina Hermans
NatuRAPT Research Group, University of Antwerp, Antwerp, Belgium
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Guido R Y De Meyer
Guido R Y De Meyer
Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium
Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Wim Martinet
Wim Martinet
Laboratory of Physiopharmacology, University of Antwerp, Antwerp, Belgium
Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium
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underline the importance of GPX4 in preventing lipid peroxidation and associated cell death. Because lipid peroxidation and iron deposition contribute significantly to the pathogenesis of atherosclerosis ( 11 , 12 ), targeting of cell death mediated by
Ornella Colpani
Ornella Colpani
IRCCS MultiMedica, Milan, Italy
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Gaia Spinetti
Gaia Spinetti
IRCCS MultiMedica, Milan, Italy
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hypertension and atherosclerosis ( 7 ). Both endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) are affected by acquiring a senescent phenotype with distinct characteristics as briefly described below ( Fig. 1 ). Figure 1 Aging
Majid Almansouri
Majid Almansouri
Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
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Pooja Patel
Pooja Patel
Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
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Janet Chamberlain
Janet Chamberlain
Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
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Sheila Francis
Sheila Francis
Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
Healthy Lifespan Institute HELSI, University of Sheffield, Medical School, Sheffield, UK
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Healthy Lifespan Institute HELSI, University of Sheffield, Medical School, Sheffield, UK
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Introduction Atherosclerosis is a multifactorial chronic inflammatory disease characterised by excess blood lipids which become modified, entering the vessel wall and driving the disease process ( 1 ). A key modification is that of LDL to
Raafat Mohamed
Raafat Mohamed
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland, Australia
Department of Basic Sciences, College of Dentistry, University of Mosul, Mosul, Iraq
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Department of Basic Sciences, College of Dentistry, University of Mosul, Mosul, Iraq
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Reearna Janke
Reearna Janke
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland, Australia
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Wanru Guo
Wanru Guo
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland, Australia
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Yingnan Cao
Yingnan Cao
Department of Pharmacy, Xinhua College of Sun Yat-sen University, Guangzhou, China
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Ying Zhou
Ying Zhou
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland, Australia
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Wenhua Zheng
Wenhua Zheng
Faculty of Health Sciences, University of Macau, Taipa, Macau, China
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Hossein Babaahmadi-Rezaei
Hossein Babaahmadi-Rezaei
Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Atherosclerosis Research Center, Ahvaz, Iran
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Suowen Xu
Suowen Xu
Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
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Danielle Kamato
Danielle Kamato
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland, Australia
Department of Pharmacy, Xinhua College of Sun Yat-sen University, Guangzhou, China
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Department of Pharmacy, Xinhua College of Sun Yat-sen University, Guangzhou, China
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Peter J Little
Peter J Little
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, Queensland, Australia
Department of Pharmacy, Xinhua College of Sun Yat-sen University, Guangzhou, China
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Department of Pharmacy, Xinhua College of Sun Yat-sen University, Guangzhou, China
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inflammatory cytokines, extracellular matrix production, contraction and differentiation ( 65 ). Oxidative stress is the one of the major contributors to the pathophysiology of many diseases, including cardiovascular diseases (CVDs) such as atherosclerosis
Stijntje Hibender
Stijntje Hibender
Amsterdam UMC Location University of Amsterdam, Department of Medical Biochemistry, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
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Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
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Siyu Li
Siyu Li
Amsterdam UMC Location University of Amsterdam, Department of Medical Biochemistry, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
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Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
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Alex V Postma
Alex V Postma
Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
Amsterdam UMC Location University of Amsterdam, Department of Medical Biology, Meibergdreef, Amsterdam, The Netherlands
Amsterdam UMC Location University of Amsterdam, Department of Human Genetics, Meibergdreef, Amsterdam, The Netherlands
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Amsterdam UMC Location University of Amsterdam, Department of Medical Biology, Meibergdreef, Amsterdam, The Netherlands
Amsterdam UMC Location University of Amsterdam, Department of Human Genetics, Meibergdreef, Amsterdam, The Netherlands
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Myrthe E Hoogeland
Myrthe E Hoogeland
Amsterdam UMC Location University of Amsterdam, Department of Medical Biochemistry, Meibergdreef, Amsterdam, The Netherlands
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Denise Klaver
Denise Klaver
Amsterdam UMC Location University of Amsterdam, Department of Medical Biochemistry, Meibergdreef, Amsterdam, The Netherlands
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Richard B Pouw
Richard B Pouw
Sanquin Research, Department of Immunopathology, Plesmanlaan, Amsterdam, The Netherlands
Amsterdam UMC Location University of Amsterdam, Landsteiner Laboratory, Meibergdreef, Amsterdam, The Netherlands
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Amsterdam UMC Location University of Amsterdam, Landsteiner Laboratory, Meibergdreef, Amsterdam, The Netherlands
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Hans W Niessen
Hans W Niessen
Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
Amsterdam UMC Location University of Amsterdam, Department of Pathology, Meibergdreef, Amsterdam, The Netherlands
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Amsterdam UMC Location University of Amsterdam, Department of Pathology, Meibergdreef, Amsterdam, The Netherlands
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Antoine HG Driessen
Antoine HG Driessen
Amsterdam UMC Location University of Amsterdam, Heart Center, Department of Cardiothoracic Surgery, Meibergdreef, Amsterdam, The Netherlands
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David R Koolbergen
David R Koolbergen
Amsterdam UMC Location University of Amsterdam, Heart Center, Department of Cardiothoracic Surgery, Meibergdreef, Amsterdam, The Netherlands
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Carlie JM de Vries
Carlie JM de Vries
Amsterdam UMC Location University of Amsterdam, Department of Medical Biochemistry, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
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Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
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Marieke JH Baars
Marieke JH Baars
Amsterdam UMC Location University of Amsterdam, Department of Human Genetics, Meibergdreef, Amsterdam, The Netherlands
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Arjan C Houweling
Arjan C Houweling
Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
Amsterdam UMC Location University of Amsterdam, Department of Human Genetics, Meibergdreef, Amsterdam, The Netherlands
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Amsterdam UMC Location University of Amsterdam, Department of Human Genetics, Meibergdreef, Amsterdam, The Netherlands
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Paul A Krijnen
Paul A Krijnen
Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
Amsterdam UMC Location University of Amsterdam, Department of Pathology, Meibergdreef, Amsterdam, The Netherlands
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Amsterdam UMC Location University of Amsterdam, Department of Pathology, Meibergdreef, Amsterdam, The Netherlands
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Vivian de Waard
Vivian de Waard
Amsterdam UMC Location University of Amsterdam, Department of Medical Biochemistry, Meibergdreef, Amsterdam, The Netherlands
Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
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Amsterdam Cardiovascular Sciences, Atherosclerosis & Ischemic Syndromes, Amsterdam, The Netherlands
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reduced circulating TNFα and less aortic macrophage accumulation. TNFα has a crucial function in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis ( 42 ). However, inhibition of this signaling
Ka Ka Ting
Ka Ka Ting
Centre for the Endothelium Vascular Biology Program Centenary Institute, The University of Sydney, Sydney, New South Wales, Australia
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Paul Coleman
Paul Coleman
Centre for the Endothelium Vascular Biology Program Centenary Institute, The University of Sydney, Sydney, New South Wales, Australia
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Yang Zhao
Yang Zhao
Centre for the Endothelium Vascular Biology Program Centenary Institute, The University of Sydney, Sydney, New South Wales, Australia
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Mathew A Vadas
Mathew A Vadas
Centre for the Endothelium Vascular Biology Program Centenary Institute, The University of Sydney, Sydney, New South Wales, Australia
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Jennifer R Gamble
Jennifer R Gamble
Centre for the Endothelium Vascular Biology Program Centenary Institute, The University of Sydney, Sydney, New South Wales, Australia
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regulation of blood fluidity, hemostasis and clotting, vascular tone, immune responses, inflammation, angiogenesis, and metabolism ( 2 ). Dysfunction of the endothelium is a major contributor to cardiovascular diseases (CVD) such as stroke, atherosclerosis
Manisha S Patil
Manisha S Patil
Heart Research Institute, Sydney, Australia
Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Siân P Cartland
Siân P Cartland
Heart Research Institute, Sydney, Australia
Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Mary M Kavurma
Mary M Kavurma
Heart Research Institute, Sydney, Australia
Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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diseases such as atherosclerosis ( 3 , 4 ). TNF-related apoptosis-inducing ligand (TRAIL) was discovered for its unique ability to selectively kill cancer cells ( 5 , 6 ). In the vasculature, TRAIL has a multifunctional role. In addition to cell death
Sara Sileno
Sara Sileno
Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory Via Monti di Creta, Rome, Italy
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Sara Beji
Sara Beji
Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory Via Monti di Creta, Rome, Italy
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Marco D’Agostino
Marco D’Agostino
Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory Via Monti di Creta, Rome, Italy
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Alessandra Carassiti
Alessandra Carassiti
Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory Via Monti di Creta, Rome, Italy
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Guido Melillo
Guido Melillo
Unit of Cardiology, IDI-IRCCS, Via Monti di Creta, Rome, Italy
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Alessandra Magenta
Alessandra Magenta
Institute of Translational Pharmacology (IFT), National Research Council of Italy (CNR), Via Fosso del Cavaliere, Rome, Italy
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-related comorbidities ( 7 , 8 ) and the atherogenic side-effects of systemic therapies for psoriasis have also been reported ( 9 ). Atherosclerosis and inflammation in psoriatic patients Ample research work has demonstrated that inflammation is a key driver of
