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Piotr Kobialka and Mariona Graupera

regulatory mechanisms which prevent from uncontrolled vascular growth, a pathological situation frequently occurring in diseases (e.g. tumour growth, vascular eye disease or overgrowth syndromes) ( 1 , 2 ). PI3K ( p hosphatidyl i nositol 3 - k inase

Open access

Timothy D Le Cras and Elisa Boscolo

The phosphoinositide 3-kinase pathway The phosphoinositide 3-kinase (PI3K) signaling pathway is a critical regulator of the angiogenic process by controlling endothelial cell (EC) proliferation, migration and survival ( 1 ). Growth factor

Open access

James T Pearson, Mikiyasu Shirai, Vijayakumar Sukumaran, Cheng-Kun Du, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T Waddingham, Rajesh Katare and Daryl O Schwenke

treatment rescued endothelial function and promoted angiogenesis in a hindlimb ischemia mouse model through potentiation of proangiogenic, antifibrotic and antiapoptotic pathways including activation of PI3K/Akt, vascular endothelial growth factor and

Open access

Raafat Mohamed, Reearna Janke, Wanru Guo, Yingnan Cao, Ying Zhou, Wenhua Zheng, Hossein Babaahmadi-Rezaei, Suowen Xu, Danielle Kamato and Peter J Little

Ras/mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathways thus regulating multiple cellular processes such as differentiation, proliferation, migration and cell survival ( 58 ). In rat neonatal

Open access

Eleonora Foglio, Laura Pellegrini, Antonia Germani, Matteo Antonio Russo and Federica Limana

myocardial ischemia/reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway . Biochemical and Biophysical Research Communications 2018 843 – 849 . ( https://doi.org/10.1016/j.bbrc.2018.02.121 ) 37 Xu W

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Amer Harky, Ka Siu Fan and Ka Hay Fan

SB Zhu J Zhou ZZ Xi EP Wang RP Zhang Y . TGF-β1 induces human aortic vascular smooth muscle cell phenotype switch through PI3K/AKT/ID2 signaling . American Journal of Translational Research 2015 2764 – 2774 . 87 Takeda N Hara H

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Ornella Colpani and Gaia Spinetti

. While ABT263 binds and blocks BCL2/Bcl-xL, quercetin acts by blocking diverse steps of JNK, PI3K, RAS/RAF/MEK/ERK and NF-kB pathways. In addition to senescent cell removal, scientists are striving to find an approach to reverse senescence

Open access

Makeda Stephenson, Daniel H Reich and Kenneth R Boheler

mesoderm differentiation could be initiated in monolayers of hPSCs using chemically defined medium (CDM), containing polyvinyl alcohol (PVA), fibroblast growth factor (FGF)-2, LY294002 (an inhibitor of phosphoinositide 3-kinases (PI3K)), and BMP4 for 1