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Malik Bisserier, Radoslav Janostiak, Frank Lezoualc’h and Lahouaria Hadri

Background Pulmonary arterial hypertension (PAH) is a vascular remodeling disease characterized by an increase of PVR and an elevation of PAP ≥25 mmHg at rest or 30 mmHg with exercise, leading to RV failure and ultimately death ( 1 , 2 , 3