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imaged 1 h after microinjections. For visualisation of vascular leakage, embryos were mounted in 0.7% low-melting-point agarose (Sigma) and imaged with the Zeiss Axioplan Airy (25× oil/0.8 NA objective, confocal mode). Imaging and image analysis
Leeuwenhoek Centre for Advanced Microscopy, Section Molecular Cytology at Swammerdam Institute for Life Sciences, the University of Amsterdam, Amsterdam, the Netherlands
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Department of Molecular Hematology, Sanquin Research, and Landsteiner Laboratory, Molecular Cell Biology Lab, Amsterdam, the Netherlands
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Leeuwenhoek Centre for Advanced Microscopy, Section Molecular Cytology at Swammerdam Institute for Life Sciences, the University of Amsterdam, Amsterdam, the Netherlands
Department of Molecular Hematology, Sanquin Research, and Landsteiner Laboratory, Molecular Cell Biology Lab, Amsterdam, the Netherlands
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thrombin on noninflamed murine endothelial cells in their in vivo permeability assays, which is a more severe permeability-inducer compared to neutrophil TEM, which by itself does not induce vascular leakage ( 38 , 39 , 40 ). Intravital imaging of
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(normally degraded by ACE2) which through the kinin receptor B1 (B1R) causes vascular leakage and inflammation. (E) ADAM17 mediated proteolytic cleavage of ACE2 is upregulated by endocytosed SARS-CoV-2 spike proteins. Activation of the AT1R by elevated Ang
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. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo . Journal of Biological Chemistry 2007 282 23910 – 23918 . ( https://doi.org/10.1074/jbc.M702169200 ) 10.1074/jbc.M702169200 37 Siddiqui MR Komarova YA Vogel SM Gao X
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.00038.2010 ) 30 Koh YJ Kim HZ Hwang SI Lee JE Oh N Jung K Kim M Kim KE Kim H Lim NK et al . Double antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakage . Cancer
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inflammatory inhibitor IL10 was also observed ( 55 ), probably an attempt of the host tissue to block the virus-mediated inflammation. Most of these ILs cause endothelial fenestration and vascular leakage as well as production of excessive extracellular matrix
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University Heart Center, Cardiology, University Hospital Zurich, Zürich, Switzerland
Department of Research and Education, University Hospital Zurich, Zürich, Switzerland
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expression was reduced retinas of STZ-induced diabetic mice and in high glucose-exposed endothelial cells. In experimental mouse models, knockdown of MEG3 was associated with increased number of a cellular capillaries, increased vascular leakage, and
Wihuri Research Institute, Helsinki, Finland
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Wihuri Research Institute, Helsinki, Finland
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vivo ischemia protection ( 13 , 36 , 37 , 55 ). Importantly, the vascular effects did not include vascular leakage, unlike with VEGF overexpression. Intramyocardial adenoviral or AAV-mediated overexpression of VEGF-B167 in the rat heart prevented
