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Makeda Stephenson, Daniel H Reich and Kenneth R Boheler

Introduction Vascular smooth muscle cells (vSMCs) develop from cell lineage precursors and progenitors to form a layer of non-striated contractile mural cells located between the tunica media and tunica adventitia of blood vessels which

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Ornella Colpani and Gaia Spinetti

vascular system that dramatically increase during aging. Senescence of endothelial and vascular smooth muscle cells Several observations indicate that aging and senescence are processes which contribute to the onset of cardiovascular diseases, and

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Raafat Mohamed, Reearna Janke, Wanru Guo, Yingnan Cao, Ying Zhou, Wenhua Zheng, Hossein Babaahmadi-Rezaei, Suowen Xu, Danielle Kamato and Peter J Little

serine/threonine kinase receptors (S/TKR) notably transforming growth factor (TGF)-β type 1 receptor (TGFBR1). In human vascular smooth muscle cells (VSMCs), treatment with thrombin ( 12 , 13 ) or endothelin-1 (ET-1) ( 14 , 15 ) stimulates carboxy

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Linda Alex and Nikolaos G Frangogiannis

, are coated by vascular smooth muscle cells. Pericytes are ubiquitously found in all organs and contribute to vascular maturation and stability, by regulating capillary permeability and by restraining endothelial cell proliferation. In addition to their

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Stephen P Gray, Ajay M Shah and Ioannis Smyrnias

phox , Rac/yes Post-translational modification of regulatory subunits Cardiomyocytes, endothelial cells, fibroblasts, vascular smooth muscle cells, inflammatory cells NOX4 Constitutively active None/yes Poldip2 and transcriptional

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Xuechong Hong and Wenduo Gu

EA Chandy M Besla R Li CC Momen A El-Mounayri O Robbins CS Husain M . c -Myb regulates proliferation and differentiation of adventitial Sca1 + vascular smooth muscle cell progenitors by transactivation of myocardin . Arteriosclerosis

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Alessandra Magenta, Reggio Lorde, Sunayana Begum Syed, Maurizio C Capogrossi, Annibale Puca and Paolo Madeddu

vasoactive stimuli and mount reparative transformation upon tissue damage. Zooming into the molecular level, aging of the vasculature consists in small, incremental amounts of damage that spreads to all vascular cells, including vascular smooth muscle cells

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Amer Harky, Ka Siu Fan and Ka Hay Fan

vascular smooth muscle cell contractility . Circulation Research 2013 327 – 340 . ( https://doi.org/10.1161/CIRCRESAHA.113.300675 ) 27 Zhou YL Zhang YY Cheng BL Xu D Tang LF Chen ZM . Multisystemic smooth muscle dysfunction syndrome in

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James T Pearson, Mikiyasu Shirai, Vijayakumar Sukumaran, Cheng-Kun Du, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T Waddingham, Rajesh Katare and Daryl O Schwenke

, vascular smooth muscle cells. AG inhibits endothelin-1 and directly reduces vasomotor tone It was established in early studies following the discovery of ghrelin that acute administration of AG lowers arterial blood pressure ( 8 , 9

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Malik Bisserier, Radoslav Janostiak, Frank Lezoualc’h and Lahouaria Hadri

MG Graham BB Tuder RM . Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension . Cardiovascular Research 2018 551 – 564 . ( https://doi.org/10.1093/cvr/cvy004 ) 7 Chin KM Kim