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Alessandra Magenta, Reggio Lorde, Sunayana Begum Syed, Maurizio C Capogrossi, Annibale Puca, and Paolo Madeddu

Regenerative medicine is a new therapeutic modality that aims to mend tissue damage by encouraging the reconstitution of physiological integrity. It represents an advancement over conventional therapies that allow reducing the damage but result in disease chronicization. Age-related decline in spontaneous capacity of repair, especially in organs like the heart that have very limited proliferative capacity, contributes in reducing the benefit of conventional therapy. ncRNAs are emerging as key epigenetic regulators of cardiovascular regeneration. Inhibition or replacement of miRNAs may offer reparative solutions to cardiovascular disease. The first part of this review article is devoted to illustrating novel therapies emerging from research on miRNAs. In the second part, we develop new therapeutic concepts emerging from genetics of longevity. Prolonged survival, as in supercentenarians, denotes an exceptional capacity to repair and cope with risk factors and diseases. These characteristics are shared with offspring, suggesting that the regenerative phenotype is heritable. New evidence indicates that genetic traits responsible for prolongation of health span in humans can be passed to and benefit the outcomes of animal models of cardiovascular disease. Genetic studies have also focused on determinants of accelerated senescence and related druggable targets. Evolutionary genetics assessing the genetic basis of adaptation and comparing successful and unsuccessful genetic changes in response to selection within populations represent a powerful basis to develop novel therapies aiming to prolong cardiovascular and whole organism health.

Open access

David Mellis and Andrea Caporali

demonstrated that post-transcriptional regulation of 14q32 miRNAs is mediated by the cold-inducible RBP (CIRBP) and hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta (HADHB) during vascular regeneration after ischaemia ( 14

Open access

Xuechong Hong and Wenduo Gu

. ( https://doi.org/10.1126/science.284.5411.143 ) 2 Gu W Hong X Potter C Qu A Xu Q . Mesenchymal stem cells and vascular regeneration . Microcirculation 2017 24 . ( https://doi.org/10.1111/micc.12324 ) 3 Klein D . Vascular wall

Open access

Eleonora Zucchelli, Qasim A Majid, and Gabor Foldes

culture condition is still needed to assess phenotype stability and maintenance of functional properties of hPSC-EC after several passages in culture ( 30 ). Finally, mesenchymal stem cells (MSCs) have shown vascular regeneration properties in vitro and in

Open access

Makeda Stephenson, Daniel H Reich, and Kenneth R Boheler

? Hypertension 2005 454 – 462 . ( https://doi.org/10.1161/01.HYP.0000177474.06749.98 ) 16103272 7 Boheler KR . Pluripotency of human embryonic and induced pluripotent stem cells for cardiac and vascular regeneration . Thrombosis and Haemostasis 2010