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Makeda Stephenson, Daniel H Reich and Kenneth R Boheler

-directed, but specific cell types can be induced depending on the addition of growth factors at specific times of cultivation ( 16 , 17 , 18 ). (B) Phenotype-driven protocols seek to generate either synthetic or contractile vSMCs through phenotype switching

Open access

Amer Harky, Ka Siu Fan and Ka Hay Fan

SB Zhu J Zhou ZZ Xi EP Wang RP Zhang Y . TGF-β1 induces human aortic vascular smooth muscle cell phenotype switch through PI3K/AKT/ID2 signaling . American Journal of Translational Research 2015 2764 – 2774 . 87 Takeda N Hara H

Open access

Malik Bisserier, Radoslav Janostiak, Frank Lezoualc’h and Lahouaria Hadri

of phenotype switch-related marker alpha smooth muscle actin (α-SMA) ( 183 ) in PASMCs. Finally, it is now well-known that altered PDGF signaling contributes to the PAH pathogenesis. However, the underlying mechanism remains not fully understood