Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Introduction Organoids should comprise at least two cell types which further organize into a 3D structure recapitulating some of the key features of the native organ ( 1 ). Although organoids have gained significant attention in the academic
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, high doses of TNFα suppressed angiogenesis. The presence of pericytes appeared to modulate this switch, where the presence of pericytes rescued the antiangiogenic effects of TNFα at high doses to become proangiogenic. Organoids Recently, there
Austrian Cluster for Tissue Regeneration, Vienna, Austria
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Austrian Cluster for Tissue Regeneration, Vienna, Austria
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Austrian Cluster for Tissue Regeneration, Vienna, Austria
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organoids/mini-organs, resulting in organ-on-a-chip systems, which rely on functional vasculature as well ( 4 ). As a rather new process 3D bioprinting has also been considered as an approach for successful vascularization with a wide range of applicability
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Heart and Vascular Center, Semmelweis University, Budapest, Hungary
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cellular settings can provide us with consistent performance with reduced cell culture artefacts and permit continuous and quantitative imaging. We suggest that scaffold-based cell constructs, as well as organoids, spheroids, hydrogels, and bioprinting (3D
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Department of Biomedical Sciences, University of Sassari, Viale San Pietro, Sassari, Italy
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as the lung and the kidney ( 20 ). In this regard, recent data obtained in engineered human blood vessel organoids derived frm induced pluripotent stem cells confirmed that SARS-CoV-2 can directly infect blood vessel cells. Indeed, SARS-CoV-2-infected
Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands
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model heart diseases in vitro , including the use of human organoids (i.e. heart-on-a-chip), and 3D-cell printing techniques ( 114 , 115 ). These in vitro techniques are ideal for drug testing and determining therapies in personalized medicine
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of tissues from human pluripotent stem cells . Current Stem Cell Reports 2016 43 – 51 . ( https://doi.org/10.1007/s40778-016-0030-z ) 27330934 87 Clevers H . Modeling development and disease with organoids . Cell 2016 1586 – 1597