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) show the formation of a necrotic core within the plaques in the absence of SASP. Interestingly, reduced expression of TRF2 has been associated with senescent VSMCs in human atherosclerotic lesions ( 14 ). MicroRNAs are master regulators of
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risk factors, leading the authors to conclude that psoriasis is independently associated with the presence of CAD ( 19 ). Finally, a strict correlation between the duration of psoriasis and the extension of CAD exists. microRNA involved in psoriasis
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Introduction to miRNAs in vascular biology MicroRNAs (miRNAs) are a member of the small non-coding RNA family; they are ~22 nucleotides and are strong post-transcriptional regulator of gene expression. The specificity of miRNA targeting is
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Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA
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manuscript. Acknowledgement The authors acknowledge the support of the Abigail Wexner Research Institute at Nationwide Children’s Hospital. References 1 Bartel DP MicroRNAs: genomics, biogenesis, mechanism, and function [Internet] . Cell
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activation of target genes. BRD4 is upregulated in lungs, distal PAs, and PASMCs of patients with PAH compared with healthy donors ( 94 ). Mechanistically, microRNA-204 upregulated BRD4 expression in PAH. Pharmacological inhibition of BRD4 with JQ1
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Division of Cardiology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA
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Department of Medicine, Surgery and Dentistry, ‘Scuola Medica Salernitana’ University of Salerno, Baronissi, Italy
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. LncRNAs and circRNAs that sponge miRNA-21 miR-21 is a highly expressed microRNA in the cardiovascular system; it attenuates inflammation, maladaptive remodeling, and cardiac dysfunction in post myocardial infarction ( 96 ). Recent studies have reported
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University Heart Center, Cardiology, University Hospital Zurich, Zürich, Switzerland
Department of Research and Education, University Hospital Zurich, Zürich, Switzerland
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pharmacological intervention, with several compounds already available ( 52 ). microRNAs and cardiovascular damage in obesity and diabetes Together with DNA methylation and histone marks, ncRNAs are critically involved in obesity and diabetes
Department of Physiology and Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia
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functional angiogenesis in a mouse model of critical limb ischemia through activation of proangiogenic microRNAs . Endocrinology 2016 432 – 445 . ( https://doi.org/10.1210/en.2015-1799 ) 25 Neale JPH Pearson JT Katare R Schwenke DO . Ghrelin
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various angiogenic regulators including transcription factors, growth factors, bioactive lipids, as well as epigenetic regulators such as microRNA (miR) and long-noncoding RNA that together may better orchestrate tissue repair and regeneration ( 46 , 47
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attenuated adverse remodeling and improved systolic dysfunction, by secreting angiogenic mediators (such as VEGF and angiopoietin-1) and by releasing protective microRNAs ( 75 ). Pericyte-derived miR-132 was identified a key cardioprotective factor that