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Alessandra Magenta, Reggio Lorde, Sunayana Begum Syed, Maurizio C Capogrossi, Annibale Puca, and Paolo Madeddu

through the regulation of miR-101/EZH2 pathway causing cancer ( 109 , 110 ). Genetics of extreme longevity: can this inform new therapy sustaining health-span? Although prolonged lifespan does not always correspond to health span, extreme

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Amer Harky, Ka Siu Fan, and Ka Hay Fan

factors towards formation of thoracic aneurysm ( 44 ). Genetics of aortic aneurysm and dissection With TAAD being the result of dysfunctional physiology of the aortic wall, it follows that there are genetic factors involved in altering the

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Timothy D Le Cras and Elisa Boscolo

.1542/peds.2014-3673 ) 12 Brouillard P Vikkula M . Vascular malformations: localized defects in vascular morphogenesis . Clinical Genetics 2003 63 . ( https://doi.org/10.1034/j.1399-0004.2003.00092.x ) 13 Garzon MC Huang JT Enjolras O

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Piotr Kobialka and Mariona Graupera

.1126/scitranslmed.aaf1164 ) 55 Liaw D Marsh DJ Li J Dahia PLM Wang SI Zheng Z Bose S Call KM Tsou HC Peacoke M , Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome . Nature Genetics 1997

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Malik Bisserier, Radoslav Janostiak, Frank Lezoualc’h, and Lahouaria Hadri

. The DNA methyltransferases of mammals . Human Molecular Genetics 2000 2395 – 2402 . ( https://doi.org/10.1093/hmg/9.16.2395 ) 39 Jones PA Liang G. Rethinking how DNA methylation patterns are maintained . Nature Reviews Genetics 2009

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Sashini Iddawela, Andrew Ravendren, and Amer Harky

Harky A Fan KS Fan KH The genetics and biomechanics of thoracic aortic diseases . Vascular Biology 2019 1 R13 – R25 . ( https://doi.org/10.1530/VB-19-0027 ) 41 Kerwin W Pepin M Mitsumori L Yarnykh V Schwarze U Byers P MRI of

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Xuechong Hong and Wenduo Gu

transcription factor TCF21 regulates smooth muscle precursor cells that contribute to the fibrous cap . PLoS Genetics 2015 11 e1005155 . ( https://doi.org/10.1371/journal.pgen.1005155 ) 17 Tang Z Wang A Yuan F Yan Z Liu B Chu JS Helms JA

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Sarah Costantino, Shafeeq A Mohammed, Samuele Ambrosini, and Francesco Paneni

. Circulation: Cardiovascular Genetics 2010 3 567 – 573 . ( https://doi.org/10.1161/CIRCGENETICS.110.958744 ) 6 Handy DE Castro R Loscalzo J . Epigenetic modifications: basic mechanisms and role in cardiovascular disease . Circulation 2011

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Raafat Mohamed, Reearna Janke, Wanru Guo, Yingnan Cao, Ying Zhou, Wenhua Zheng, Hossein Babaahmadi-Rezaei, Suowen Xu, Danielle Kamato, and Peter J Little

-9149(02)03144-2 ) 114 Lusis AJ , Mar R & Pajukanta P . Genetics of Atherosclerosis . Annual Reviews of Genomics and Human Genetics 2004 5 189 – 218 . ( https://doi.org/10.1146/annurev.genom.5.061903.175930 ) 115 Griendling KK Sorescu D Lassegue

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David Mellis and Andrea Caporali

Murphy D Sevignani C Wentzel E Furth EE Lee WM Enders GH Mendell JT , Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster . Nature Genetics 2006 38 . ( https://doi.org/10.1038/ng1855 ) 35 Bonauer A Carmona G