. When implanted into immune-tolerant rats following a myocardial infarction, the implants could regenerate myocardium within 4 weeks, suggesting that hiPSC-derived engineered tissues are capable of in vivo repair and regeneration. Additional proof
Makeda Stephenson, Daniel H Reich and Kenneth R Boheler
Jaana Schneider, Marianne Pultar and Wolfgang Holnthoner
Upon implantation, engineered tissues rely on the supply with oxygen and nutrients as well as the drainage of interstitial fluid. This prerequisite still represents one of the current challenges in the engineering and regeneration of tissues. Recently, different vascularization strategies have been developed. Besides technical approaches like 3D printing or laser processing and de-/recelluarization of natural scaffolds, mainly co-cultures of endothelial cells (ECs) with supporting cell types are being used. This mini-review provides a brief overview of different co-culture systems for the engineering of blood and lymphatic microvascular networks.
Ebba Brakenhielm and Vincent Richard
engineered tissues . Acta Biomaterialia 2018 69 42 – 62 . ( https://doi.org/10.1016/j.actbio.2018.01.017 ) 3 Carrabba M Madeddu P . Current strategies for the manufacture of small size tissue engineering vascular grafts . Frontiers in