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Ka Ka Ting, Paul Coleman, Yang Zhao, Mathew A Vadas, and Jennifer R Gamble

Introduction The endothelial cell (EC) monolayer forms the inner cellular lining of all blood vessels forming a critical interface between blood and tissue ( 1 ). Vascular endothelium is involved in physiological functions, which include

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Aurélie Hautefort, Anna Pfenniger, and Brenda R Kwak

arterial endothelium of the common carotid artery (b) and at the carotid bifurcation (C). Nuclei are stained with DAPI (in blue). Scare bar represents 30 µm. Small muscular arteries and arterioles regulate arterial blood pressure and blood flow

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Jarkko P Hytönen, Olli Leppänen, Jouni Taavitsainen, Petra Korpisalo, Svetlana Laidinen, Kari Alitalo, Jonas Wadström, Tuomas T Rissanen, and Seppo Ylä-Herttuala

graft. (B and C) CD31 immunohistology for endothelial cells shows the luminal endothelium reaching from the adjacent carotid artery at day 28 (C). There are no significant differences in transanastomotic endothelialization between the groups (D). Arrow

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T Scott Bowen and Stuart Egginton

iono/osmo regulation, and impact immune reaction. By virtue of their huge surface area the endothelium is an important interface between systemic hormonal signalling and tissue metabolic responses. Consequently, endothelial dysfunction is known to make

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David Mellis and Andrea Caporali

-endothelialisation following endothelial injury in mice by stimulating endothelial migration and proliferation upon transfer of functional miR-126 to target endothelium, with subsequent downregulation of SPRED1 ( 42 ). We have demonstrated that NF-kB signalling induced miR-503

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Karthik Amudhala Hemanthakumar and Riikka Kivelä

now recognized that the endothelium is much more than only a transport system for blood flow and that endothelial cells (ECs) play a variety of important roles during cardiac development and in growth and homeostasis of the adult heart. The adult human

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Roberta Giordo, Panagiotis Paliogiannis, Arduino Aleksander Mangoni, and Gianfranco Pintus

pathophysiological role of the endothelium in COVID-19 onset and progression. Vascular endothelial cells form a highly effective barrier between the circulation and peripheral tissues and play a key role in the maintenance of vessel tone, hemostasis, immune response

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Chia-Pei Denise Hsu, Joshua D Hutcheson, and Sharan Ramaswamy

flow are an essential environmental factor that activate the vascular endothelium. However, in addition to mechanotransduction properties, flow also directs secondary effects associated with chemical signaling, such as, for example, the transport of

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Tatiane Gorski and Katrien De Bock

Schoors S Oellerich MF Lim R Zimmermann B Aspalter IM Franco CA Boettger T , et al . FOXO1 couples metabolic activity and growth state in the vascular endothelium . Nature 2016 529 216 – 220 . ( https://doi.org/10.1038/nature16498 ) 72 Longchamp

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Paolo Madeddu

discovery of the endothelium-derived relaxing factor (EDRF; i.e. NO ( 4 )), while clinically inspired investigations led to the recognition of the pathophysiological relevance of neoangiogenesis in cancer and tissue healing. This brought about the proposal