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Majid Almansouri Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK

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Pooja Patel Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK

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Janet Chamberlain Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK

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Sheila Francis Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, UK
Healthy Lifespan Institute HELSI, University of Sheffield, Medical School, Sheffield, UK

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-1β by caspase-1 ( 9 ). Active IL-1β can then be associated with the NLRP3 inflammasome ( 10 ). Only active IL-1β is released from cells and there is a myriad of mechanisms proposed, mainly in monocytic cells, including through microvesicles

Article Type:
Research Article
DOI:
https://doi.org/10.1530/VB-22-0009
Volume/Issue:
Volume 4: Issue 1
Open access
Manisha S Patil Heart Research Institute, Sydney, Australia
Faculty of Medicine and Health, University of Sydney, Sydney, Australia

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Siân P Cartland Heart Research Institute, Sydney, Australia
Faculty of Medicine and Health, University of Sydney, Sydney, Australia

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Mary M Kavurma Heart Research Institute, Sydney, Australia
Faculty of Medicine and Health, University of Sydney, Sydney, Australia

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endothelial cell line, hCMEC/D3 ( 63 ). Instead, in these cells, TRAIL stimulated caspase-1 activity and cell death ( 60 , 63 ). These discrepancies may reflect receptor expression, cell type, origin, or differences in the in vitro angiogenic assay methods

Article Type:
Review Article
DOI:
https://doi.org/10.1530/VB-20-0005
Volume/Issue:
Volume 2: Issue 1
Open access
Sara Sileno Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory Via Monti di Creta, Rome, Italy

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Sara Beji Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory Via Monti di Creta, Rome, Italy

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Marco D’Agostino Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory Via Monti di Creta, Rome, Italy

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Alessandra Carassiti Istituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory Via Monti di Creta, Rome, Italy

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Guido Melillo Unit of Cardiology, IDI-IRCCS, Via Monti di Creta, Rome, Italy

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Alessandra Magenta Institute of Translational Pharmacology (IFT), National Research Council of Italy (CNR), Via Fosso del Cavaliere, Rome, Italy

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associated with both PASI improvement and local inflammatory response decrease ( 36 ). Interestingly, in MI, miR-135b is downregulated, and its overexpression attenuates pyroptosis, a caspase-1-dependent proinflammatory programmed cell death. Thus, miR-135b

Article Type:
Review Article
DOI:
https://doi.org/10.1530/VB-21-0007
Volume/Issue:
Volume 3: Issue 1
Open access