Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
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vascularization is achieved. During organ development, blood vessels usually grow simultaneously to not only nourish but also remodel and reshape the organs. Lack of vascularization limits the size, complexity, maturation and function of organoids. Emerging
Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Faculty of Medicine and Health, University of Sydney, Sydney, Australia
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Introduction Blood vessels, consisting of arteries, arterioles, capillaries, venules and veins, are channels with intricate networks that supply blood around the body and remove waste. Most blood vessels are composed of three layers ( Fig. 1
Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal
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Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
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physically connected via the lymphatic thoracic duct, where lymph returns macromolecules and extravasated fluid to the blood circulation. Blood vessels arise during early embryonic development. De novo formation of blood vessels – vasculogenesis – is
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Introduction Over the last 15 years, the use of anti-angiogenic agents to inhibit blood vessel growth has clearly established its ‘raison d’être’ in the treatment of human diseases, including multiple types of cancer, but also vascular
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Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
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Mechanisms of vessel formation Over recent decades, the epidemic of cardiovascular disorders, and in particular cardiac ischemia, has raised an enormous interest on the mechanisms sustaining blood vessel formation, with the final goal of
ProCure Research Program, Instituto de Salud Carlos III, Madrid, Spain
OncoBell Program, Instituto de Salud Carlos III, Madrid, Spain
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ProCure Research Program, Instituto de Salud Carlos III, Madrid, Spain
OncoBell Program, Instituto de Salud Carlos III, Madrid, Spain
CIBERONC, Instituto de Salud Carlos III, Madrid, Spain
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Tissue homeostasis is maintained through a functional network of blood vessels that provide nutrients and oxygen and remove the metabolic waste and carbon dioxide. Therefore, it is of little surprise that the cardiovascular system is one of the
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microvascular systems is incorporating multiple cell types in a physiologically relevant environment and spatial arrangement. Interactions between endothelial and mural cells are critical for forming and stabilizing the vasculature. Blood vessels are lined with
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vascular development ( 34 ). Nevertheless, the vcl- KO embryos develop functional blood vessels and no evident haemorrhages were observed ( 34 ). To assess the permeability of the endothelial barrier, the 10 kDa rhodamine-dextran tracer was injected into
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Introduction Cancer and stromal accessory cells co-evolve to foster malignant growth and tumour progression. Among stromal cells, tumour blood vessels have been a major focus in oncology. It has been shown in the early 1970s that the rate of
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Heart and Vascular Center, Semmelweis University, Budapest, Hungary
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combination of cells in tandem with an array of factors and signalling cascades. Moreover, other than blood vessels, another type of vasculature exists, which form the lymphatic network. Lymphatic vessels are unidirectional, blind-ended capillaries, which
