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Piotr Kobialka and Mariona Graupera

first to develop during mammalian embryogenesis. While the primitive vascular plexus arises de novo from mesoderm-derived cells (the so-called angioblasts), the majority of vessels develop by sprouting angiogenesis, a process of vessel formation from

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Tatiane Gorski and Katrien De Bock

muscle fibers increases within seconds ( 5 , 6 , 7 ). In response to repeated exercise bouts, the formation of new capillaries from existing ones, a highly dynamic and tightly controlled process termed angiogenesis, is initiated ( 8 , 9 ). The increase

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Eleonora Zucchelli, Qasim A Majid and Gabor Foldes

, stroke, peripheral artery disease and other ischaemic cardiovascular diseases. Furthermore, the unregulated expansion of the vasculature during tumour angiogenesis can have detrimental consequences resulting in cancer metastasis. However, repair of the

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James T Pearson, Mikiyasu Shirai, Vijayakumar Sukumaran, Cheng-Kun Du, Hirotsugu Tsuchimochi, Takashi Sonobe, Mark T Waddingham, Rajesh Katare and Daryl O Schwenke

( 20 ). Thus, chronic AG treatment improves endothelium-independent and -dependent vasodilation and the regulation of perfusion. AG reduces vascular injury and enhances angiogenesis Various lines of evidence indicate that AG and DAG both exert

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Linda Alex and Nikolaos G Frangogiannis

reperfused myocardium has been implicated in the pathogenesis of ‘no-reflow’. During the proliferative phase, pericytes activated by growth factors may regulate angiogenesis and fibrosis. To what extent pericyte to fibroblast conversion contributes to the

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Ebba Brakenhielm and Vincent Richard

and repair. Yet, here we are, after 50 years of active research to decipher the cellular and molecular mechanisms regulating vasculogenesis, angiogenesis and arteriogenesis, still lacking a firm solution of how to build stable and functional blood

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David Mellis and Andrea Caporali

, with miRNAs being established one of the major post-transcriptional regulatory elements in vascular biology. Among the miRNAs deposited in miRBase, 42 have been described as associated with endothelial cell function and angiogenesis ( 3 ). The ability

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Jarkko P Hytönen, Olli Leppänen, Jouni Taavitsainen, Petra Korpisalo, Svetlana Laidinen, Kari Alitalo, Jonas Wadström, Tuomas T Rissanen and Seppo Ylä-Herttuala

therapeutic applications have emerged. We have consistently shown in normal and ischemic skeletal muscles as well as in myocardium that transient overexpression of VEGF receptor-2 ligands promotes capillary arterialization and sprouting angiogenesis, induces

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Ruth Ganss

tumour neovascularisation – or angiogenesis – controls tumour growth ( 1 ). Subsequently, Folkman’s hypothesis of blocking tumour angiogenesis as a means to starve cancers ( 2 ) triggered decades of molecular studies into the pathophysiology of

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T Scott Bowen and Stuart Egginton

Angiogenesis Angiogenesis, the growth of new blood vessels from an existing capillary bed ( de novo creation of capillaries, neovascularisation, is a distinct process), is not only essential in the maintenance of tissue/organ health, but also