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proportional cellular responses to maintain the endothelial barrier ( 10 ). VE–cadherin-based adherens junctions (AJs) are crucial adhesion structures that form endothelial cell–cell contacts ( 11 , 12 ). Endothelial junction remodelling is required for
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signalling can induce tyrosine phosphorylation of VE-cadherin at Tyr658 and Tyr731 via the activation of two tyrosine kinases, Src and Pyk2 ( 49 ). VE-cadherin is a major constituent of adherens junctions and connects ECs by binding to the actin cytoskeleton
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have demonstrated the importance of direct EC–pericyte contact for cell–cell communication through physical interactions, including gap junctions, such as connexin 43 ( 13 ), and adherens junctions, specifically N-cadherin ( 14 ). However, constructing
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. Phosphorylated FOXO1 will enter the EC tip nuclei and promote transcription of polarity and migration-related genes. YAP/TAZ transcription factors are crucial for the activation of CDC42 and for adherens junction’s integrity and stabilization. WNT5A/ROR2
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by the presence of not only adherens junctions (AJs) but also a molecularly unique and complex as well as continuous network of TJs ( 12 ). The transmembrane vascular endothelial cadherin (VE-cadherin) mediates homophilic adhesion at the level of BBB
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in the endothelial barrier, however, means that the process must be tightly controlled. ECs are connected to each other by adherens junctions and tight junctions to form a barrier that excludes all but small molecules ( 4 ). The organization of these
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intercellular space and adherens junctions (AJs) providing mechanical anchorage ( 36 ), recent evidence suggests that GJs and/or Cxs may play a role in the regulation of the endothelial barrier function as well ( 37 ). Cx40 is abundantly expressed in the lung
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adherens junction molecules such as vascular endothelial (VE)-cadherin ( 24 ). In addition, endothelial cells of a normalised vasculature are supported by higher numbers of pericytes or pericytes which are more mature and adhesive ( 13 , 20 , 22 ). While
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-receptor interaction, WnT signaling, metabolism Tmem100, Scn7a, Adrb1, Daam1, Nkd1 MG JAK-STAT, NOD-like receptor signaling, MAPK signaling Emp1 Atf4, Dusp5, Gadd45b, Myc, Relb Pancreas Adherens junction, focal adhesion, MAPK
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Carvalho JR Hollfinger I Bartels-Klein E Franco CA YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development . eLife 2018 7 e31037. ( https://doi.org/10.7554/eLife.31037 ) 69 Kwon HB
