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Sara Sileno, Sara Beji, Marco D'Agostino, Alessandra Carassiti, Guido Melillo, and Alessandra Magenta

Psoriasis is a chronic inflammatory disease involving skin. Both genetic and environmental factors play a pathogenic role in psoriasis and contribute to the severity of the disease. Psoriasis, in fact, has been associated with different comorbidities such as diabetes, metabolic syndrome, gastrointestinal or kidney diseases, cardiovascular diseases (CVD), and cerebrovascular diseases (CeVD). Indeed, life expectancy in severe psoriasis is reduced by up to 5 years due to CVD and CeVD. Moreover, patients with severe psoriasis have a higher prevalence of traditional cardiovascular (CV) risk factors, including dyslipidaemia, diabetes, smoking, and hypertension. Further, systemic inflammation is associated with oxidative stress increase and induces endothelial damage and atherosclerosis progression.

Different microRNAs have been already described in psoriasis, both in the skin tissues and in the blood flow, to play a role in the progression of disease. In this review we will summarize and discuss the most important miRNAs that play a role in psoriasis and have been also linked to CVD.