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Ka Ka Ting, Paul Coleman, Yang Zhao, Mathew A Vadas, and Jennifer R Gamble

indeed endothelial dysfunctions including arterial stiffening ( 6 ), impaired neovascularization ( 7 ) and loss of tissue-barrier function are evident in age-related diseases ( 8 ). This review will focus on cellular aging or senescence of the vascular

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Alessandra Magenta, Reggio Lorde, Sunayana Begum Syed, Maurizio C Capogrossi, Annibale Puca, and Paolo Madeddu

/medical welfare are in the agenda of policy makers and governmental agencies. All around the world, scientists are trying to beat age-related diseases, such as heart attacks, cancer, and dementia; stop people getting ill is an obvious goal to aid the individual

Open access

Ambra Cappelletto and Serena Zacchigna

research on aged animals is extremely costly and is impossible to perform in most laboratories, requiring animal housing for prolonged periods of time. The execution of pre-clinical trials in aged companion animals, which share most age-related diseases

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Sarah Costantino, Shafeeq A Mohammed, Samuele Ambrosini, and Francesco Paneni

123 2145 – 2156 . ( https://doi.org/10.1161/CIRCULATIONAHA.110.956839 ) 7 Brunet A Berger SL . Epigenetics of aging and aging-related disease . Journals of Gerontology: Series A, Biological Sciences and Medical Sciences 2014 69

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Amer Harky, Ka Siu Fan, and Ka Hay Fan

divisions. Telomere shortening in age-related diseases such as cardiovascular diseases have been proven to reflect cellular turnover and shows potential within TAAD cases ( 44 ). The biological ageing effect of telomere attrition can also be caused by