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Karthik Amudhala Hemanthakumar and Riikka Kivelä

protected the mice from rupture following MI and induced hypertrophy with aging. • In an 8-week TAC mouse model, deletion of periostin decreased cardiac hypertrophy and fibrosis. • During the first 10 days after myocardial infarction the mice lacking

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David Mellis and Andrea Caporali

. ( https://doi.org/10.1038/ncomms10521 ) 9 Ungvari Z Tucsek Z Sosnowska D Toth P Gautam T Podlutsky A Csiszar A Losonczy G Valcarcel-Ares MN Sonntag WE , Aging-induced dysregulation of dicer1-dependent microRNA expression impairs

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Malik Bisserier, Radoslav Janostiak, Frank Lezoualc’h, and Lahouaria Hadri

development, in genomic imprinting, X-chromosome inactivation, and repression of transposable elements, aging, and carcinogenesis ( 16 , 17 , 18 ). There are three major layers of epigenetic modifications: DNA methylation, histone modifications, and ncRNAs

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Roberta Giordo, Panagiotis Paliogiannis, Arduino Aleksander Mangoni, and Gianfranco Pintus

endothelial cells and in response to virus spike protein activates the Nlrp3 inflammasome . Stem Cell Reviews and Reports 2020 1 – 12 . ( https://doi.org/10.1007/s12015-020-10010-z ) 30 Xudong X Junzhu C Xingxiang W Furong Z Yanrong L Age

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Tatiane Gorski and Katrien De Bock

network is a reversible cause of vascular aging . Cell 2018 173 e20 . 68 Potente M Ghaeni L Baldessari D Mostoslavsky R Rossig L Dequiedt F Haendeler J Mione M Dejana E Alt FW , et al . SIRT1 controls endothelial angiogenic functions during

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Catarina G Fonseca, Pedro Barbacena, and Claudio A Franco

8 a018226 . ( https://doi.org/10.1101/cshperspect.a018226 ) 12 Goley ED Welch MD . The Arp2/3 complex: an actin nucleator comes of age . Nature Reviews: Molecular Cell Biology 2006 7 713 – 726 . ( https://doi.org/10.1038/nrm2026