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Sarah Costantino, Shafeeq A Mohammed, Samuele Ambrosini, and Francesco Paneni

impaired glucose tolerance and 592 million people will have diabetes worldwide ( 1 ). A recent study analysing data from 6,264,226 adults (18 years of age or older) who participated in the Behavioral Risk Factor Surveillance System Survey (1993–1994 and

Open access

Manisha S Patil, Siân P Cartland, and Mary M Kavurma

processes are essential in vascular remodelling where structural changes to the blood vessel wall are necessary during normal physiology, aging, injury, and disease. Cells act in response to the ECM and remodel, but this process becomes impaired in vascular

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Eleonora Zucchelli, Qasim A Majid, and Gabor Foldes

kinases (using sunitinib) ( 17 , 18 ) are among the most promising therapeutic strategies. Moreover, anti-VEGF and PDGF therapies have been reported to effectively decrease angiogenesis in patients affected by age-related macular degeneration and diabetic

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Kor H Hutting, Wouter B aan de Stegge, Rombout R Kruse, Jeff G van Baal, Sicco A Bus, and Jaap J van Netten

Declaration of Helsinki. Based on our experience with patients hospitalized with DFIs in our center, we used a convenience sample of patients included during a 6-month study duration. We included patients (age >18 years) with type 1 or 2 diabetes mellitus

Open access

Abdallah Al-Mohammad, David G Partridge, Graham Fent, Oliver Watson, Nigel T Lewis, Robert F Storey, Michael Makris, and Timothy J Chico

necrosis) and cardiac imaging, including point-of-care echocardiography. What is clear is that pre-existing cardiac conditions such as diabetes and hypertension, as well as older age significantly increase the risk of mortality or adverse outcome in SARS

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Stephen P Gray, Ajay M Shah, and Ioannis Smyrnias

proliferation, which are essential steps in the development of atherosclerosis ( 42 , 49 ). Xu et al. ( 43 ) reported that NOX4 expression was increased in aged atherosclerotic plaques, specifically in the SMC of unstable plaques, through an increase in SMC

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Gloria Garoffolo and Maurizio Pesce

Zhang HJ . Disruption of mechanical stress in extracellular matrix is related to Stanford type A aortic dissection through down-regulation of yes-associated protein . Aging 2016 8 1923 – 19 39 . ( ) 60 Li

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Cristina Caffarra Malvezzi, Aderville Cabassi, and Michele Miragoli

the scar were utilized. (B) Representative optical images (color-coded isochrones) for AMC cell (local propagation) and infarcted-16-week-old cells (total-propagation). (C) Frequency of propagated mechanical induced Ca 2+ transient (MiCai) in aged

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Sandra Neumann, Elena G Milano, Chiara Bucciarelli-Ducci, and Giovanni Biglino

, age and ethnicity ( 3 ) allowing for standardization of the method as well as reference ranges to be calculated for smaller studies. CIMT imaging has been validated against in vitro histology ( 5 , 6 ). Success rates for imaging the common carotid

Open access

Makeda Stephenson, Daniel H Reich, and Kenneth R Boheler

dysfunction can lead to vascular complications or disease, which contribute significantly to morbidity and mortality, particularly with aging ( 6 , 7 ). While animal models and primary human vSMC culture systems have contributed to our understanding of