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Malik Bisserier, Radoslav Janostiak, Frank Lezoualc’h, and Lahouaria Hadri

characterization of new therapeutic targets for treating PAH are necessary. Epigenetic mechanisms Epigenetics is defined as a heritable change occurring in the genome resulting in a change of gene expression without affecting the DNA sequence ( 14 ). These

Open access

Alessandra Magenta, Reggio Lorde, Sunayana Begum Syed, Maurizio C Capogrossi, Annibale Puca, and Paolo Madeddu

oxidative stress, mitochondrial dysfunction, susceptibility to molecular stressors, chronic low-grade inflammation, genomic instability, cellular senescence, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, and stem cell

Open access

Sarah Costantino, Shafeeq A Mohammed, Samuele Ambrosini, and Francesco Paneni

identify new targets and design breakthrough therapies in this growing patient population. Epigenetic regulation of gene expression Accumulating evidence suggests that the ‘non-genetic’ regulation of vascular function is gaining increasing attention

Open access

Gloria Garoffolo and Maurizio Pesce

The role of mechanical forces is emerging as a new player in pathophysiologic programming of the cardiovascular system. The ability of the cells to ‘sense’ mechanical forces does not relate only to perception of movement or flow, as intended traditionally, but also to the biophysical properties of the extracellular matrix, the geometry of the tissues and the force distribution inside them. This is also supported by the finding that cells can actively translate mechanical cues into discrete gene expression and epigenetic programming. In the present review we will contextualize these new concepts in the vascular pathologic programming.

Open access

Carlo Dal Lin, Francesco Tona, and Elena Osto

tissue destruction in case of stress persistence and chronic processes. Of note, the ‘cardioimmune’ inflammatory activation can be activated by psychological stress and the stress activated patterns can be transmitted across generations via epigenetic

Open access

Ornella Colpani and Gaia Spinetti

itself, since this could be crucial for prolonged healthy life span. Cell reprogramming could be a promising strategy since the generation of induced pluripotent stem cells (iPSCs) allows to reset epigenetic state of cells. However, this kind of approach

Open access

Xuechong Hong and Wenduo Gu

SC Spencer HL Spiteri I Sottoriva A Riu F Rowlinson J Avolio E Katare R Mangialardi G , Epigenetic profile of human adventitial progenitor cells correlates with therapeutic outcomes in a mouse model of limb ischemia

Open access

Ebba Brakenhielm and Vincent Richard

various angiogenic regulators including transcription factors, growth factors, bioactive lipids, as well as epigenetic regulators such as microRNA (miR) and long-noncoding RNA that together may better orchestrate tissue repair and regeneration ( 46 , 47

Open access

Makeda Stephenson, Daniel H Reich, and Kenneth R Boheler

human aortic vSMCs in terms of gene expression patterns, vascular cell markers (e.g., ACTA2), epigenetic states of pluripotency-related genes (e.g., OCT4), and in vitro functional properties (calcium movements in response to membrane depolarization and

Open access

Chia-Pei Denise Hsu, Joshua D Hutcheson, and Sharan Ramaswamy

Research 2004 95 459 – 470 . ( ) 28 Hove JR Koster RW Forouhar AS Acevedo-Bolton G Fraser SE Gharib M . Intracardiac fluid forces are an essential epigenetic factor for embryonic