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Ka Ka Ting, Paul Coleman, Yang Zhao, Mathew A Vadas, and Jennifer R Gamble

. Endothelial cell senescence in age-related diseases CVD and cerebrovascular diseases are the leading causes of death in the elderly population ( 48 ). EC dysfunction is a well-accepted hallmark of age-related vascular dysfunction, with the initiation of

Open access

Gloria Garoffolo and Maurizio Pesce

The role of mechanical forces is emerging as a new player in pathophysiologic programming of the cardiovascular system. The ability of the cells to ‘sense’ mechanical forces does not relate only to perception of movement or flow, as intended traditionally, but also to the biophysical properties of the extracellular matrix, the geometry of the tissues and the force distribution inside them. This is also supported by the finding that cells can actively translate mechanical cues into discrete gene expression and epigenetic programming. In the present review we will contextualize these new concepts in the vascular pathologic programming.

Open access

Sarah Costantino, Shafeeq A Mohammed, Samuele Ambrosini, and Francesco Paneni

epigenetic marks - were associated with gene upregulation, mitochondrial oxidative stress and impaired availability of nitric oxide, eventually leading to vascular dysfunction. Of note, restoration of normoglycemia was not able to erase the activating marks

Open access

Nektarios Barabutis

function by reducing the ROS levels. P53 suppression resulted to an increased reactive oxygen species production, associated with reduced TEER values, indicating vascular dysfunction ( 7 ). Anti-inflammatory agents, initially developed to fight

Open access

T Scott Bowen and Stuart Egginton

mitochondrial ROS production is intimately involved in vascular dysfunction, the underlying signalling cascades and how mitochondrial function impacts angiogenesis remain poorly understood. Ischaemia/inflammation One clue may come from the response to

Open access

Paolo Madeddu

II levels also further increases ADAM17 activity. Soluble ACE2 can act as a blocking receptor for SARS-CoV-2. (F) After replication and cellular damage, the virus spreads to other cells causing incremental injury and vascular dysfunction

Open access

Ebba Brakenhielm and Vincent Richard

, notably maintenance of vascular barrier, with increased vascular permeability reported in diabetes, for example, in dermal capillaries in humans ( 26 ) and in bone marrow capillaries in mice ( 27 ). Consideration of such multicellular vascular dysfunctions