Microcirculation special issue


Advances in the live imaging of microcirculation

Guest Editor: Dr Ayman Al Haj Zen


Aims & Scope

The circulatory system transports blood containing nutrients, oxygen, waste products, and metabolites throughout the body. However, the exchange of blood components occurs mainly at the level of microcirculation. Microcirculation is a network of blood vessels comprising arterioles, capillaries, and venules. Anatomical or functional disturbances of microcirculation could have significant implications in the pathogenesis of chronic diseases such as diabetes, hypertension, rheumatic disease, and ischemic vascular disease. A wide range of live imaging techniques has been used to assess microcirculation's morphology and function, including laser speckle contrast imaging, two-photon intravital microscopy, near-infrared fluorescent imaging, optical coherence microangiography, and capillaroscopy. Besides, live imaging of microcirculation has been an essential tool in animal studies to unpinning the cellular dynamics in sprouting angiogenesis and leukocyte transmigration. Non-invasive imaging of microvasculature would be advantageous to better understand the pathophysiological processes that link disease and microcirculation abnormalities, achieve early disease detection, and redefine the prognosis of these abnormalities in various contexts of vascular medicine.

This special issue aims to highlight recent research on evaluating the microcirculation changes in disease through state-of-the-art live imaging methodologies in basic science, pre-clinical, or clinical settings.


Tentative dates

Open for submissions: 1/3/2021
Deadline for submission: 30/9/2021